Scaffolds to Control Inflammation and Facilitate Dental Pulp Regeneration

Inflammation of the Dental Pulp

1Department of Conservative Dentistry, College of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea 2The State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Sichuan 610042, China 3Department of Restorative Dentistry, University of Otago, School of Dentistry, Dunedin 9016, New Zealand 4Department of Oral Biological Sciences, University Lyon ...

Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration?

The importance of inflammation has been underestimated in pulpal healing, and in the past, it has been considered only as an undesirable effect. Associated with moderate inflammation, necrosis includes pyroptosis, apoptosis, and nemosis. There are now evidences that inflammation is a prerequisite for pulp healing, with series of events ahead of regeneration. Immunocompetent cells are recruited ...

Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria

1 Institut de Génomique Fonctionnelle de Lyon, Equipe Physiopathologie des Odontoblastes, Ecole Normale Supérieure de Lyon, CNRS UMR5242, Lyon, France 2 Faculté d’Odontologie, Université de Lyon, Université Lyon 1, Lyon, France 3 Hospices Civils de Lyon, Service de Consultations et Traitements Dentaires, Lyon, France 4 Faculté d’Odontologie, INSERM UMR1064, Centre de Recherche en Transplantatio...

Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells

Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. Plastic compression of collagen scaffolds seeded with MSC has been shown to enhance the osteogenic differentiation of MSC as it increases the collagen fibrillary density. The aim of the present study was to evaluate the osteogenic effe...

Pulp Regeneration by Harnessing Dental Pulp Stem Cells